Your search found 5 image(s) of leaves of Giant Ragweed and Sassafras.
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Sassafras,
Sassafras albidum
Leaves can be unlobed, mitten-shaped, or 3-lobed; margins entire, per Woody Plants of the Blue Ridge.
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Giant Ragweed,
Ambrosia trifida var. trifida
Leaves 3(5)-lobed or unlobed, tips acuminate, margins evenly serrate, per Vascular Flora of the Carolinas.
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Giant Ragweed,
Ambrosia trifida var. trifida
Leaves usually with 3-5 deep lobes, per Newcomb's Wildflower Guide.